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The review also documents neuroprotective effects, including peripheral nerve regeneration after transection and counteraction of the otherwise progressing course following traumatic brain injury

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This effect, mediated by inactivation of the phosphoinositide 3-kinase activation (PI3K/AKT) and extracellular-signal-regulated kinase (ERK) signaling pathways, offers an insight into the complex mechanisms of miscarriage and preeclampsia during Se deficiency

In tissues with higher natural HGF expression (like the hippocampus), the amplification effect is expected to be more pronounced than in tissues with low HGF