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NNMT is an enzyme that grabs nicotinamide and methylates it, turning it into a waste product called 1-MNA that gets cleared from the body

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Lipid Metabolism & 3-AR Mechanism Heffernan et al., Endocrinology (2001) Heffernan and colleagues investigated the lipolytic effects of chronic AOD-9604 treatment using two complementary mouse models: diet-induced obese C57BL/6J mice and beta3 adrenergic receptor (3-AR) knockout mice

It is believed to influence levels of dopamine, norepinephrine, and serotonin in the brain key neurotransmitters involved in satiety, mood, and metabolism