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These hybrids exhibited superior neuroprotective effects and lower cytotoxicity compared with curcumin alone, activated ARE, chelated ferrous ions and scavenged ROS, thereby protecting cells from oxidative stress and ferroptosis, ultimately promoting neuronal survival (104,127,128)

Box 1: Practical consultation tips for administration of rectal formulations Example advice given to patients for administration of suppositories: You might find it easier to use a suppository before bed to minimise any leakage

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