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Although the purpose of the study was not to conduct quantitative analyses, questionnaire data showed a trend towards reduction in PHQ-9, GAD-7 and EDE-Q scores (Table 1), which were clinically significant given that change scores of 5, 4 and 0.57 are considered the minimal clinically important differences in PHQ-9, GAD-7 and total EDE-Q scores respectively [38,39,40]

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Clinical trials showed users lost up to 12.4% of their body weight

Because of previous studies in this field using poorly characterized antibodies, 22, 25 we took particular care to use a thoroughly validated monoclonal antibody that specifically labels GLP1R-expressing cells while being negative for GLP1R-lacking cells, 23, 24 and that has a superior immunohistochemical specificity compared with several other (commercial) GLP1R antibodies