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Liraglutide (daily injectable) Dosing frequency: Once daily, same time each day Half-life: approximately 13 hours Peak concentration: 8 to 12 hours after injection Recommended timing approach: Because of the short half-life, time of day matters significantly more for liraglutide than for weekly formulations
Acid contact time with the esophageal lining increases dramatically, raising the risk of esophagitis, stricture formation, and potentially Barrett esophagus with chronic exposure
The Evidence: Efficacy Beyond the Hype The first GLP-1 agonist, exenatide (Byetta, approved in 2005), required twice-daily injections and produced modest weight loss
People with higher starting BMI Individuals with BMI above 40 often see faster absolute weight loss in the early phases, simply because a higher body weight means a larger caloric expenditure even at rest, and the same percentage reduction in food intake creates a larger absolute caloric deficit
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