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95% CI 0.360.93 and HR 0.73

With respect to insulin-mediated signaling that affects metabolism, AKT2 phosphorylates glycogen synthase kinase-3 (GSK3), ATP citrate lyase (ACYL), phosphodiesterase 3B (PDE3B), and the Rab-GTPase-activating protein encoded by the TBC1D4 (TBC1 domain family member 4) gene

What has been established is that DSIP modulates multiple neurochemical and endocrine pathways including interactions with the hypothalamic-pituitary-adrenal (HPA) axis, endogenous opioid systems, and antioxidant defence mechanisms giving it a uniquely broad functional profile for a peptide of only nine amino acids