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In light of these translational obstacles for rAAV-PHP.eB and rAAV-PHP.B, one recent study produced AAV.CPP16 by inserting cell-penetrating peptides (CCPs) into the AAV9 capsid between Q588 and A589 amino acids [168]

Furthermore, DLS was shown to provide useful information on the time-dependent conformational changes taking place during the unfolding-refolding reactions of proteins that proceed with time constants in the range of seconds or minutes (Gast et al., 1992)

High Circulating dipeptidyl peptidase 3 predicts mortality and need for organ support in cardiogenic shock: an ancillary analysis of the ACCOST-HH trial