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1.1 Glucose Metabolism is Reduced in Alzheimers and Parkinsons Disease A key element that has not received sufficient attention in understanding the pathophysiology of chronic neurodegenerative disorders such as AD and PD is the observation that glucose uptake and energy utilization in neurons is progressively reduced over time

Research found that AG reduced insulin secretion in humans or isolated islets, and a large dose of AG caused IR [82, 90,91,92]

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