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Here, we show that sustained iron overload, but not acute exposure, leads to a state of ferroptotic stress where nerve cells remain viable but become hypersensitive to oxidative injury

It is hypothesized that even in the presence of CatS/CatL inhibition and blockade of proDPP1 maturation, NSP-AAP can activate approximately 80% of NSPs

While this represents a higher per-treatment cost than oral supplements, the superior absorption and reduced frequency often make injections cost-competitive over time, particularly for those who dont absorb oral forms effectively

Lineu Prestes, 748, Cidade Universitria, So Paulo 05508-000, Brazil [email protected] This article was submitted to Chemical Biology, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers