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Please note: DSIP 5MG is intended strictly for research
This was performed by high-pressure liquid chromatography using a LC-20A Shimadzu equipment (Shimadzu GmbH, Duisburg) with an interphase module (CBM-20A, Shimadzu GmbH) and electrochemical detection (ESA Biosciences, Inc., Chelmsford, MA), with the upstream electrode set at +100 mV (for compounds with low oxidation potential) and downstream electrode set between +100 and +650 mV (in +50 mV increments) for each injected standard to determine the optimum potential for detection
As an ACAT-1 inhibitor, AVA increases membrane cholesterol levels, thereby enhancing T cell receptor signaling and cytokine secretion to boost T-cell function, and downregulates the expression of the cholesterol biosynthesis transcription factor SREBP2 and the migration-associated protein integrin V, thereby suppressing tumor invasion