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Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]
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They had a baseline glycated hemoglobin (HbA1c) level between 7.5% and 10.5% (58-91 mmol/mol), a body-mass index of 25 kg/m2 or greater, and established cardiovascular disease or a high risk of cardiovascular events
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