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Patients must work closely with healthcare providers to monitor weight changes and adjust treatment as needed (including medication dosages, nutritional strategies, and physical activities)

Freezing damage is invisible to the naked eye but destroys efficacy

Standard dose escalation: 0.25 mg weekly for 4 weeks 0.5 mg weekly for 4+ weeks 1.0 mg weekly for 4+ weeks 1.7 mg weekly if needed 2.4 mg weekly (maximum) There is no requirement to reach 2.4 mg if the patient is responding and tolerating treatment

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