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Risk factors that increase this concern include: History of peptic ulcer disease or gastrointestinal bleeding Concurrent use of anticoagulants (warfarin, apixaban) or antiplatelet agents (aspirin, clopidogrel) Use of corticosteroids or selective serotonin reuptake inhibitors (SSRIs) Chronic alcohol consumption Presence of Helicobacter pylori infection For patients taking low-dose aspirin for cardiovascular protection, ibuprofen can interfere with aspirin's antiplatelet effect

The most common side effects for both medications include: Nausea Diarrhea Constipation Vomiting Stomach pain These effects are usually mild to moderate and tend to improve over time as your body adjusts to the medication