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In an open-label, phase 3, multicenter study involving 11 children aged 25 years with biallelic POMC, PCSK1, or LEPR variants, or genetically confirmed BardetBiedl syndrome (BBS), 83% achieved a 0.2-point reduction in BMI Z score over 52 weeks, with a mean BMI reduction of 18% observed overall (26% in the POMC/LEPR group and 10% in the BBS group) [45]

Contact your GP if you experience persistent or severe nausea and vomiting preventing adequate intake, severe abdominal pain (especially upper abdomen), signs of dehydration, blood in vomit or stools, or symptoms significantly impacting your quality of life or nutritional adequacy