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Side effects that should be reported to a healthcare provider as soon as possible include: Allergic reactions such as rash, itching, or swelling of the face, lips, or tongue Breathing problems Bloody or black stools Symptoms of kidney stones (blood in urine or lower back pain) Symptoms of liver injury such as yellowing of the skin or eyes Trouble passing urine Uncontrolled or urgent bowel movements Vomiting Side effects that may not require medical attention include:[2] Gas Increased bowel movements Oily stools Upset stomach Ozempic Ozempic is a medication injected once weekly into the thigh, abdomen, or upper arm

The prevalence of vitamin B12 deficiency is particularly elevated among patients with T2D, with studies demonstrating that up to 64% of those with DPN exhibit altered (low or borderline) vitamin B12 levels compared with only 17% of patients without neuropathy

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5.2 Discontinuation Is the Binding Constraint Roughly 20% of patients discontinue GLP-1 therapy early and another 32% discontinue later in their treatment course, meaning more than half of patients who start semaglutide or tirzepatide are no longer on drug a year later