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It is noteworthy that a study using a humanized liver ApoE 4/4 mouse model found that mice with the ApoE 4/4 genotype exhibited significantly lower plasma ApoE4 levels compared to those with the ApoE 2/3 genotype

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Nrf2 was found to participate in transcriptional activation of antioxidant enzymes that act as a cell defensive system to detoxify NAPQI (Goldring et al., 2004)

This matters because oxidative stress is tied to everyday wear and tear, internal signaling, and how well cells recover from lifes various challenges