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Mitochondrial ROS are increased under hypoxia, ischemia/reperfusion injury, chemical stress, drug treatment, and under many pathophysiological conditions (Srinivasan and Avadhani, 2012)

Human studies support these findings: A randomized controlled trial demonstrated that a six-month zinc supplementation regimen in older adults increased plasma zinc levels and decreased markers of inflammation, including high-sensitivity C-reactive protein, IL-6, MCP-1, and VCAM-1