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[4] [5] However, these studies predominantly involved populations with pre-diabetes or metabolic syndrome, and results may not generalise to individuals seeking weight loss without metabolic dysfunction

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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity), a phase 3 study involving 17,604 adults with overweight or obesity and pre-existing CVD but no diabetes, revealed that once-weekly subcutaneous semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% compared with placebo over a mean follow-up of 39.8 months, including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke [48]

Some people simply respond better to one amino acid than the other due to differences in metabolism, enzyme activity, and overall health status