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Tirzepatide produced greater average weight and waist reduction, while gastrointestinal adverse events were most common with both medications and were generally mild to moderate

Methods A realist synthesis, through a complexity-informed lens, was undertaken to develop initial program theories

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There is also an increased desire to urinate and the medication is not indicated in patients with type 1 diabetes, or patients with frequent ketones in their blood or urine, severe renal impairment, end stage renal disease or patients receiving dialysis