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Furthermore, we review the pharmacokinetics and pharmacodynamics of both native ghrelin and synthetic ghrelin ligands used clinically to date, and propose that augmenting their blood brain barrier (BBB) penetrability would better target the GHSR-1a at the level of feeding and reward centres in the brain, thus increasing specificity for appetite-modulation and limiting off-target peripheral tissue effects
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Critical factors of vanillin assay for catechins and proanthocyanidins
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