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It has been evaluated in six human clinical trials for functional dyspepsia and related upper GI symptoms, including indigestion, occasional heartburn, abdominal discomfort and bloating

SERT Ala56 mice that expressed an ASD-associated variant in humans exhibited elevations of 5-HT clearance in the brain and ASD-related social impairments and repetitive behavior, but forebrain 5-HT levels did not change in the mutants (149)

Total RNA was extracted from with Trizol reagent (Beyotime, Shanghai, China) according to the manufacturers instructions