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3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion ( Lipotoxicity induced by saturated free fatty acids plays a vital role in renal injury in obese patients ( There is little research on the weight loss effect of EX on simple obesity patients, and more clinical trials are conducted on patients with T2DM
Clinicians check IGF-1 before starting treatment to establish a baseline
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More recently, innovative molecules like the dual glucose-dependent insulinotropic polypeptide and the glucagon-like peptide 1 (GLP1R-GIPR) receptors agonists, such as tirzepatide, have shown even greater efficacy, with weight loss up to 18% [21]
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