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COX-2 is an N-glycoprotein with 4 glycosylation sites 33 , and it has been shown that inhibition of COX-2 N-glycosylation by site-directed mutagenesis or pharmacologically using an N-glycosylation inhibitor leads to the production of a COX-2 protein with reduced molecular mass and activity 34

Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia

Eating slowly and chewing properly is also essential

GLP-1 is a Weight and Health Game Changer Articles about GLP-1 effect are appearing more and more in the US media