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CARS2 mutant lacking the persulfide synthesis activity did not rescue the decreased mitochondrial membrane potential of CASR2-deficient cells, whereas CARS2 mutant lacking cysteinyl t-RNA synthesis activity did

More recently, in vivo proteomic approaches of SCI have demonstrated that peripheral nerve injury alters the expression and/or subcellular distribution of some specific dorsal horn proteins, for example those involved in nociceptive signaling, cellular metabolism, plasma membrane receptor trafficking, oxidative stress, apoptosis and degeneration (Lee et al., 2003

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Immunomodulator-based combination strategies aim to both enhance host antifungal defenses and directly kill the pathogen, representing a frontier in antifungal therapy (Pirofski and Casadevall, 2006)