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Transitions from telogen to anagen are not binary switches but orchestrated programs initiated when dermal papilla cell number, identity, and secretory cues reach permissive thresholds to recruit epithelial stem cells

Laboratory investigations using ionizing radiation-induced senescent cells demonstrate that FOXO4-DRI causes p53 nuclear exclusion and mitochondrial targeting, validating the proposed mechanism of selective senescent cell elimination through targeted protein-protein interaction disruption

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