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Regulation of myelin structure and conduction velocity by perinodal astrocytes
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Women with specific FTO or MC4R variants may gain weight more easily during the menopausal transition and may benefit from higher GLP-1 doses or dual-compound therapy like GLP-Squared
Adverse effects observed in trials to date include: Gastrointestinal symptoms nausea, vomiting, diarrhoea, and constipation (common with GLP-1 receptor agonists) Reduced appetite and weight loss , which may be excessive in some individuals Elevated heart rate , a concern noted with glucagon receptor agonism As with other incretin-based therapies, there is also a class-level signal for acute pancreatitis and gallbladder disease (including cholelithiasis and cholecystitis)
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