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Relative to these non-peptidic controls, the docked neuromedin C displays a markedly broader footprint, including extracellular involvement, which is a hallmark of peptide-mediated receptor activation

FIGURE 5 Ferroptosis, a regulatory cell death mode, is characterized by iron-dependent and lipid peroxide (LPO) accumulation, proposed by 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death

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