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Its methylation levels are carefully controlled by a ternary writing-erasing-reading regulatory system: writers, also known as methyltransferases, include Wilms tumor 1 associated protein (WTAP), methyltransferase-like 3 (METTL3), and methyltransferase-like 14 (METTL14), which are responsible for installing the m 6 A modification

Peer review Peer review information Nature Communications thanks Byoung-Joon Song, and the other, anonymous, reviewers for their contribution to the peer review of this work

**Quality and Purity Standards** This Retatrutide research peptide is manufactured under GMP conditions using solid-phase peptide synthesis and purified via HPLC to achieve 99% HPLC purity