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The British Obesity and Metabolic society recommend intramuscular injection of vitamin B 12 should be taken every three weeks in RYGB and BPD/DS patients, since the deficiency of B 12 still exists in the presence of higher doses of the oral supplement [120]

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212 Similarly, H4K12la enhances glutamate-cysteine ligase (GCLC) expression, which is crucial for glutathione synthesis and inhibiting lipid peroxidation, leading to chemoresistance in CRC stem cells by inhibiting ferroptosis

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