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By exposure to renal epithelial cell medium supplemented with a combination of bone morphogenetic protein, activin A and FGF, human ESCs were induced to differentiate into proximal tubular-like cells (234)

[34] Vitamin K is required for the gamma-carboxylation of specific glutamic acid residues within the Gla domain of the 17 vitamin Kdependent proteins

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Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides