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The 6-month cessation rate was 22.5% among trial participants who did not change their smoking habits before a designated quit date and then went cold turkey, compared with 15.5% for participants who were told to reduce the number of cigarettes they smoked each day by 75% over the 2 weeks before their designated quit date (relative risk 0.71, 95% CI 0.46-0.91), reported Nicola Lindson-Hawley, PhD, of the University of Oxford in England, and colleagues in the Annals of Internal Medicine

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Confounders are everywhere: many e-cigarette users are former smokers still experiencing residual metabolic effects of recent nicotine use, and younger demographics (who vape at higher rates) tend to have lower BMI regardless