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The G allele of a second variant in the region, rs7096169 (intronic to BORCS7 and only in weak LD with rs12780116, r 2 = 0.18 in 1000G Europeans) increases smoking initiation and reduces expression of BORCS7 and AS3MT in eight brain tissues (including dorsolateral prefrontal cortex in the Brain xQTL and was the top BORCS7 eSNP in GTEx in the Cerebellar Hemisphere, Cerebellum, and Spinal cord cervical-C1)

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Indeed, both former and current smokers had significantly higher frequencies of CD4 + CD45RO + ILC3s in the blood than non-smoker asthma patients (Fig

This may be why the four Senate Democrats who opposed the 2012 cigarette tax hike primarily had constituents residing near the border