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The authors found that pretreatment with nicotine greatly alters the response to cocaine in terms of addiction-related behavior and synaptic plasticity (changes in synaptic strength) in the striatum, a brain region critical for addiction-related rewards
Lowering nicotine levels to minimally addictive or non-addictive levels would decrease the likelihood that future generations of young people become addicted to cigarettes and help more currently addicted smokers to quit. The FDA has stated its intent to issue the rule by May 2023, but the process of adopting a rule like this requires a years-long process of public comments and courtroom action
I just got a machine on loan from Sally at Fresh Choice and, while I've only given it a brief try, my experience pretty much mirrors yours (and writing is painful for me :-)
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