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The genetic instrument for CSI comprised by 90 SNPs with independent and robust associations with the lifetime smoking exposure indicator was associated with the risk of both HPV-negative HNSCC [IVW OR (95% CI) = 2.59 (1.37, 4.92), P = 0.0004] and HPV-positive HNSCC [IVW OR (95% CI) = 2.6 (1.2, 5.65), P = 0.02]

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Izrael D, Hoaglin DC, Battaglia MP

These toxins illustrate how smoking affects your vision at a cellular level, accelerating tissue breakdown and clouding of the lens Long-Term Eye Health Risks Chronic smoking dramatically raises your odds of: Age-Related Macular Degeneration (AMD): Smokers are up to twice as likely to develop AMD, and they do so earlier than non-smokers