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Note that when strength of association (defined as the magnitude of the relative risk in the exposed group compared with that in the control group) is mentioned throughout this section, it refers to one of the five criteria used to decide whether a positive association in epidemiologic studies indicates causality

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[6] Among all preventable diseases, disabilities, and deaths in the US, cigarette smoking is the leading cause, contributing to 20% of all deaths, equating to 480,000 per year

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