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"Many signals tied into developmental pathways," said the study's lead author Dr Bonnie Joubert, an epidemiologist at the US National Institute of Environmental Health Sciences (NIEHS), noting that changes were seen in genes relating to lung and nervous system development, smoking-related cancers, and birth defects such as cleft lip and cleft palate

It was first synthesized in Bulgaria in 1964 as Tabex and later spread to other countries in Eastern Europe and Asia, where it is still marketed

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