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Studies have shown a direct correlation between smoking prevalence and TB incidence at a population level, suggesting that tobacco use acts as a significant driver of the TB epidemic in these regions, contributing to increased transmission, disease progression, and mortality (WHO Global, 2024

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Nicorette should be used with caution in cases of: - systemic hypertension cerebrovascular disease - stable angina pectoris - regardless compensated heart failure - vasospasm - peripheral vascular disease ulcer - active duodenal ulcers - excessive thyroid - insulin dependent diabetes (lower insulin doses may be necessary after quitting smoking) - pheochromocytoma (because nicotine provides for the release of catecholamines from the adrenal medulla) - moderate to severe hepatic Only in cases of severe kidney damage, the separation of nicotine metabolites or the related metabolism in jeopardy

2016 Behavioral Risk Factor Surveillance System Results. Available at: 7 Centers for Disease Control and Prevention