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Heartburn can affect anyone, but certain factors can increase the risk of developing it, such as obesity, pregnancy, smoking, and certain medical conditions such as hiatal hernia or scleroderma

There are other limitations

AE [1] Press release, At INC-5.2, CNCT and Surfrider advocate for a global ban on cigarette filters, CNCT, published on August 1, 2025, consulted the same day [2] Damian Carrington, 'Total infiltration': How plastics industry swamped vital global treaty talks, The Guardian, published July 23, 2025, accessed August 1, 2025 National Committee Against Smoking |

The study optimizes the current evidence-based practice for smoking cessation treatment (NRT with brief behavioral counseling) using a personalized dosing approach