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These brands sold over 900 million worth of vapes in 12 months, equivalent to around 160 million units, according to NielsenIQ

Nicotine C-oxidation to nicotine 5(1)iminium ion is followed by a second oxidation that generates cotinine, which is further metabolized to trans 3-hydroxycotinine (3-HCOT), a reaction that is catalyzed almost exclusively by CYP2A6 (see Fig

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