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Genetic testing of affected patients disclosed two patients (2/30, 6.7%) with optic neuropathy associated with pathogenic variants affecting the SPG7 gene and five patients (5/30, 16.7%) who harbored variants of uncertain significance close to probable pathogenicity in the genes WFS1 , LOXL1 , MMP19 , NR2F1 and PMPCA
Most prominent are hay and dry grass
Each cigarette filter is ideally sized to be used on roll-up cigarettes, and can be used on 5-10 cigarettes before it needs to be replaced
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