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Forty-two RCTs that met the PICO-SD criteria were selected from the systematic review.16, 23, 29, 31, 39, 47, 104, 117, 142, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180 The results showed that bupropion significantly increased smoking cessation success rates at six months or longer compared to placebo (RR, 1.57

For instance, early onset smokers exhibit deficits in reward processing and response inhibition, whereas other behavioural effects, such as physical craving for nicotine following withdrawal are greater in adults 26,27,28,29

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