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Vast plantations were built along the rivers of Virginia, and social/economic systems were developed to grow and distribute this cash crop

Results: About 37% of 12th graders reported vaping in 2018, compared with 28% in 2017

Three metabolites are active: hydroxybupropion, which is formed via hydroxylation of the tert-butyl group of bupropion, and the amino-alcohol isomers threohydrobupropion and erythrohydrobupropion, which are formed via reduction of the carbonyl group