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Full COVID-19 GWAS summary-level data is available at FinnGen data are available at lifetime smoking at alcohol drinks per week data at: cannabis use disorder and alcohol use disorder data are available through the Psychiatric Genomics Consortium data portal: and the cannabis use data are available through the International Cannabis Consortium at: Coronary artery disease and obesity summary statistics are available through the Cardiovascular Disease Knowledge Portal: Type 2 Diabetes summary-level data is available Type 2 Diabetes Knowledge Portal: Code availability We used TwoSampleMR and MendelianRandomization R packages to perform Mendelian Randomization analysis