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Approximately 49 million Americans consuming nicotine in each year and 1.25 billion worldwide, according to the World Health Organization

Jain N, Keating MJ, Thompson PA, Ferrajoli A, Burger JA , Borthakur G, Takahashi K, Estrov ZE, Sasaki K, Fowler NH, Kadia TM, Konopleva M, Alvarado Y, Yilmaz M, DiNardo CD, Bose P, Ohanian M, Pemmaraju N, Jabbour E, Kanagal-Shamanna R, Patel K, Wang W, Jorgensen JL, Wang SA, Garg N, Wang X, Wei CJ, Crus N, Ayala A, Plunkett W, Kantarjian HM, Gandhi V, Wierda WG

1,2 Other rare but serious cardiovascular conditions that can be caused by smoking include: Peripheral artery disease (and peripheral vascular disease) : A condition in which the narrowing of blood vessels results in insufficient blood flow to arms, legs, hands, and feet

So, for adults, it could be a viable alternative to things that are really harmful, but we don't want kids using it, she adds