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It can lead to a decrease in the oxygen supply to the fetus and fetal hypoxia which is the leading cause of growth retardation and organ malformation in the developing child

This condition occurs when the essential blood clot that forms in the empty socket gets dislodged or dissolves prematurely, exposing the underlying bone and nerves to air, food, and fluids

Nicotine plays a critical role in smoking addiction and is well known to be harmful to human health, because it easily crosses the bloodbrain barrier and biological membranes [83]