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The 2022 TCN Policy Recommendations Guide provides (1) guiding principles for advancing tobacco control policies and also for working with Tribal nations and (2) a summary of the changing tobacco control landscape, including the youth e-cigarette epidemic, information on health disparities and health equity, the roadblock of policy preemption, and addressing related issues such as marijuana, e-cigarette or vaping use-associated lung injury (EVALI), and COVID-19