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Due to the high mutation rate of malignant cells with defects in the p53 pathway and the fact that mutant p53 proteins are only highly expressed in malignant tissues but absent in normal tissues, targeting mutant p53 itself has been proposed to be a promising strategy for improving the treatment of chemo- and/or radio-resistant tumours
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Information revealed in the suit against R.J Reynolds showed the company knew that menthol cigarettes, just 29 percent of the overall market, were favored by over 70 percent of black smokers
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