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Most of the nicotine goes up in smoke during some combustion, some is lost as sidestream smoke, and some simply isn't absorbed by the smoker

[23] In 2021, researchers at Johns Hopkins University analyzed the vape aerosols of popular brands such as Juul and Vuse, and found "nearly 2,000 chemicals, the vast majority of which are unidentified." [24] E-cigarette vapor contains many of the known harmful toxicants found in traditional cigarette smoke, such as formaldehyde, cadmium, and lead, though usually at a reduced percentage

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Clark Company, Glendale, California.