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To this end, there has been an increasing shift from using the gold standard endpoint of overall survival (OS) (see Sidebar 28 ), to earlier endpoints like progression free survival, overall response rate, and duration of response to achieve an accelerated approval designation from FDA

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When the ads were on the air, about 62 percent more people called the national quitline, 1-800-QUIT-NOW, for free help

They may be conducted as random screenings by different companies, organizations, and law-enforcement agencies