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Substances found in e-cigarettes and their aerosol E-cigarette aerosol is NOT harmless water vapor. It can contain harmful and potentially harmful substances, including:1 Nicotine, a highly addictive chemical that can harm adolescent brain development Cancer-causing chemicals Heavy metals such as nickel, tin, and lead Tiny particles that can be inhaled deep into the lungs Volatile organic compounds Flavorings such as diacetyl, a chemical linked to a serious lung disease